Extracellular Acidic pH Inhibits Oligodendrocyte Precursor Viability, Migration, and Differentiation
Name
Jagielska-2013-Extracellular Acidic.pdf
Size
761.23 KB
Format
Adobe PDF
Checksum (MD5)
51993b72a285142979bfce980514db65
Author(s)
Jagielska, Anna
Wilhite, Kristen D.
Van Vliet, Krystyn J.
Date Issued
September 2013
Journal
PLoS ONE
Publisher
Public Library of Science
Citation
Jagielska, Anna, Kristen D. Wilhite, and Krystyn J. Van Vliet. “Extracellular Acidic pH Inhibits Oligodendrocyte Precursor Viability, Migration, and Differentiation.” Edited by Martin Stangel. PLoS ONE 8, no. 9 (September 30, 2013): e76048.
Version
Final published version
Abstract
Axon remyelination in the central nervous system requires oligodendrocytes that produce myelin. Failure of this repair process is characteristic of neurodegeneration in demyelinating diseases such as multiple sclerosis, and it remains unclear how the lesion microenvironment contributes to decreased remyelination potential of oligodendrocytes. Here, we show that acidic extracellular pH, which is characteristic of demyelinating lesions, decreases the migration, proliferation, and survival of oligodendrocyte precursor cells (OPCs), and reduces their differentiation into oligodendrocytes. Further, OPCs exhibit directional migration along pH gradients toward acidic pH. These in vitro findings support a possible in vivo scenario whereby pH gradients attract OPCs toward acidic lesions, but resulting reduction in OPC survival and motility in acid decreases progress toward demyelinated axons and is further compounded by decreased differentiation into myelin-producing oligodendrocytes. As these processes are integral to OPC response to nerve demyelination, our results suggest that lesion acidity could contribute to decreased remyelination.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Terms of Use
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1371/journal.pone.0076048
