Morphological Transformation and Force Generation of Active Cytoskeletal Networks
Name
Bidone-2017-Morphological Transformation and F.pdf
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Author(s)
Bidone, Tamara Carla
Jung, Wonyeong
Maruri, Daniel
Borau, Carlos
Kim, Taeyoon
Kamm, Roger Dale
Date Issued
January 2017
Journal
PLoS Computational Biology
Publisher
Public Library of Science
Citation
Bidone, Tamara Carla; Jung, Wonyeong; Maruri, Daniel; Borau, Carlos; Kamm, Roger D. and Kim, Taeyoon. “Morphological Transformation and Force Generation of Active Cytoskeletal Networks.” Edited by Anand R. Asthagiri. PLOS Computational Biology 13, no. 1 (January 2017): e1005277 © 2017 Bidone et al
Version
Final published version
Abstract
Cells assemble numerous types of actomyosin bundles that generate contractile forces for biological processes, such as cytokinesis and cell migration. One example of contractile bundles is a transverse arc that forms via actomyosin-driven condensation of actin filaments in the lamellipodia of migrating cells and exerts significant forces on the surrounding environments. Structural reorganization of a network into a bundle facilitated by actomyosin contractility is a physiologically relevant and biophysically interesting process. Nevertheless, it remains elusive how actin filaments are reoriented, buckled, and bundled as well as undergo tension buildup during the structural reorganization. In this study, using an agent-based computational model, we demonstrated how the interplay between the density of myosin motors and cross-linking proteins and the rigidity, initial orientation, and turnover of actin filaments regulates the morphological transformation of a cross-linked actomyosin network into a bundle and the buildup of tension occurring during the transformation.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
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Creative Commons Attribution 4.0 International License
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DOI of Published Version
https://doi.org/10.1371/journal.pcbi.1005277
