A comparative encyclopedia of DNA elements in the mouse genome
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Kellis_A comparative.pdf
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2.17 MB
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Author(s)
Wu, Yi-Chieh
Rasmussen, Matthew D.
Bansal, Mukul S.
Kellis, Manolis
Date Issued
November 2014
Journal
Nature
Publisher
Nature Publishing Group
Citation
Yue, Feng, Yong Cheng, Alessandra Breschi, Jeff Vierstra, Weisheng Wu, Tyrone Ryba, Richard Sandstrom, et al. “A Comparative Encyclopedia of DNA Elements in the Mouse Genome.” Nature 515, no. 7527 (November 19, 2014): 355–364.
Version
Author's final manuscript
Abstract
The laboratory mouse shares the majority of its protein-coding genes with humans, making it the premier model organism in biomedical research, yet the two mammals differ in significant ways. To gain greater insights into both shared and species-specific transcriptional and cellular regulatory programs in the mouse, the Mouse ENCODE Consortium has mapped transcription, DNase I hypersensitivity, transcription factor binding, chromatin modifications and replication domains throughout the mouse genome in diverse cell and tissue types. By comparing with the human genome, we not only confirm substantial conservation in the newly annotated potential functional sequences, but also find a large degree of divergence of sequences involved in transcriptional regulation, chromatin state and higher order chromatin organization. Our results illuminate the wide range of evolutionary forces acting on genes and their regulatory regions, and provide a general resource for research into mammalian biology and mechanisms of human diseases.
MIT Department
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1038/nature13992
