Lipid-Like Nanomaterials for Simultaneous Gene Expression and Silencing In Vivo

Author(s)
Dong, Yizhou; Eltoukhy, Ahmed A.; Alabi, Christopher A.; Veiseh, Omid; Sirirungruang, Sasilada; ... Show more
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Abstract
New lipid-like nanomaterials are developed to simultaneously regulate expression of multiple genes. Self-assembled nanoparticles are capable of efficiently encapsulating pDNA and siRNA. These nanoparticles are shown to induce simultaneous gene expression and silencing both in vitro and in vivo.
Date issued
2014-03
URI
http://hdl.handle.net/1721.1/101132
Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science; Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Biology; Massachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Department of Chemistry; Koch Institute for Integrative Cancer Research at MIT
Journal
Advanced Healthcare Materials
Publisher
Wiley Blackwell
Citation
Dong, Yizhou, Ahmed A. Eltoukhy, Christopher A. Alabi, Omar F. Khan, Omid Veiseh, J. Robert Dorkin, Sasilada Sirirungruang, et al. “Lipid-Like Nanomaterials for Simultaneous Gene Expression and Silencing In Vivo.” Adv. Healthcare Mater. 3, no. 9 (March 13, 2014): 1392–1397.
Version: Author's final manuscript
ISSN
21922640
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