Lipid-Like Nanomaterials for Simultaneous Gene Expression and Silencing In Vivo
Author(s)Dong, Yizhou; Eltoukhy, Ahmed A.; Alabi, Christopher A.; Khan, Omar F.; Veiseh, Omid; Dorkin, J. Robert; Sirirungruang, Sasilada; Yin, Hao; Tang, Benjamin C.; Pelet, Jeisa M.; Chen, Delai; Gu, Zhen; Xue, Yuan; Langer, Robert; Anderson, Daniel Griffith; ... Show more Show less
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New lipid-like nanomaterials are developed to simultaneously regulate expression of multiple genes. Self-assembled nanoparticles are capable of efficiently encapsulating pDNA and siRNA. These nanoparticles are shown to induce simultaneous gene expression and silencing both in vitro and in vivo.
DepartmentInstitute for Medical Engineering and Science; David H. Koch Institute for Integrative Cancer Research at MIT; Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Biology; Massachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Department of Chemistry
Advanced Healthcare Materials
Dong, Yizhou, Ahmed A. Eltoukhy, Christopher A. Alabi, Omar F. Khan, Omid Veiseh, J. Robert Dorkin, Sasilada Sirirungruang, et al. “Lipid-Like Nanomaterials for Simultaneous Gene Expression and Silencing In Vivo.” Adv. Healthcare Mater. 3, no. 9 (March 13, 2014): 1392–1397.
Author's final manuscript