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Spatiotemporal Intracellular Nitric Oxide Signaling Captured Using Internalized, Near-Infrared Fluorescent Carbon Nanotube Nanosensors

dc.contributor.authorUlissi, Zachary W.
dc.contributor.authorSen, Fatih
dc.contributor.authorGong, Xun
dc.contributor.authorSen, Selda
dc.contributor.authorIverson, Nicole
dc.contributor.authorBoghossian, Ardemis A.
dc.contributor.authorGodoy, Luiz C.
dc.contributor.authorWogan, Gerald N.
dc.contributor.authorMukhopadhyay, Debabrata
dc.contributor.authorStrano, Michael S.
dc.contributor.authorSelda, Sen
dc.date.accessioned2016-02-24T18:49:58Z
dc.date.available2016-02-24T18:49:58Z
dc.date.issued2014-07
dc.date.submitted2014-06
dc.identifier.issn1530-6984
dc.identifier.issn1530-6992
dc.identifier.urihttp://hdl.handle.net/1721.1/101259
dc.description.abstractFluorescent nanosensor probes have suffered from limited molecular recognition and a dearth of strategies for spatial-temporal operation in cell culture. In this work, we spatially imaged the dynamics of nitric oxide (NO) signaling, important in numerous pathologies and physiological functions, using intracellular near-infrared fluorescent single-walled carbon nanotubes. The observed spatial-temporal NO signaling gradients clarify and refine the existing paradigm of NO signaling based on averaged local concentrations. This work enables the study of transient intracellular phenomena associated with signaling and therapeutics.en_US
dc.description.sponsorshipNational Science Foundation (U.S.)en_US
dc.description.sponsorshipUnited States. Dept. of Energy. Computational Science Graduate Fellowship Program (Grant DE-FG02-97ER25308)en_US
dc.description.sponsorshipUnited States. Dept. of Defense (National Defense Science and Engineering Graduate (NDSEG) Fellowship)en_US
dc.language.isoen_US
dc.publisherAmerican Chemical Society (ACS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/nl502338yen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceACSen_US
dc.titleSpatiotemporal Intracellular Nitric Oxide Signaling Captured Using Internalized, Near-Infrared Fluorescent Carbon Nanotube Nanosensorsen_US
dc.typeArticleen_US
dc.identifier.citationUlissi, Zachary W., Fatih Sen, Xun Gong, Selda Sen, Nicole Iverson, Ardemis A. Boghossian, Luiz C. Godoy, Gerald N. Wogan, Debabrata Mukhopadhyay, and Michael S. Strano. “Spatiotemporal Intracellular Nitric Oxide Signaling Captured Using Internalized, Near-Infrared Fluorescent Carbon Nanotube Nanosensors.” Nano Lett. 14, no. 8 (August 13, 2014): 4887–4894. © 2014 American Chemical Societyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.mitauthorUlissi, Zachary W.en_US
dc.contributor.mitauthorSen, Fatihen_US
dc.contributor.mitauthorSelda, Senen_US
dc.contributor.mitauthorIverson, Nicoleen_US
dc.contributor.mitauthorBoghossian, Ardemis A.en_US
dc.contributor.mitauthorGodoy, Luiz C.en_US
dc.contributor.mitauthorWogan, Gerald N.en_US
dc.contributor.mitauthorStrano, Michael S.en_US
dc.relation.journalNano Lettersen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsUlissi, Zachary W.; Sen, Fatih; Gong, Xun; Sen, Selda; Iverson, Nicole; Boghossian, Ardemis A.; Godoy, Luiz C.; Wogan, Gerald N.; Mukhopadhyay, Debabrata; Strano, Michael S.en_US
dc.identifier.orcidhttps://orcid.org/0000-0003-0771-9889
dc.identifier.orcidhttps://orcid.org/0000-0003-2944-808X
dc.identifier.orcidhttps://orcid.org/0000-0002-5166-1410
mit.licensePUBLISHER_POLICYen_US


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