Show simple item record

dc.contributor.authorChen, Sidi
dc.contributor.authorSpletter, Maria
dc.contributor.authorNi, Xiaochun
dc.contributor.authorWhite, Kevin P.
dc.contributor.authorLuo, Liqun
dc.contributor.authorLong, Manyuan
dc.date.accessioned2016-03-14T17:27:14Z
dc.date.available2016-03-14T17:27:14Z
dc.date.issued2012-02
dc.date.submitted2011-11
dc.identifier.issn22111247
dc.identifier.urihttp://hdl.handle.net/1721.1/101698
dc.description.abstractThe evolution of the brain and behavior are coupled puzzles. The genetic bases for brain evolution are widely debated, yet whether newly evolved genes impact the evolution of the brain and behavior is vaguely understood. Here, we show that during recent evolution in Drosophila, new genes have frequently acquired neuronal expression, particularly in the mushroom bodies. Evolutionary signatures combined with expression profiling showed that natural selection influenced the evolution of young genes expressed in the brain, notably in mushroom bodies. Case analyses showed that two young retrogenes are expressed in the olfactory circuit and facilitate foraging behavior. Comparative behavioral analysis revealed divergence in foraging behavior between species. Our data suggest that during adaptive evolution, new genes gain expression in specific brain structures and evolve new functions in neural circuits, which might contribute to the phenotypic evolution of animal behavior.en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (Doctoral Dissertation Improvement Grant DEB-1110607)en_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.celrep.2011.12.010en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/en_US
dc.sourceElsevieren_US
dc.titleFrequent Recent Origination of Brain Genes Shaped the Evolution of Foraging Behavior in Drosophilaen_US
dc.typeArticleen_US
dc.identifier.citationChen, Sidi, Maria Spletter, Xiaochun Ni, Kevin P. White, Liqun Luo, and Manyuan Long. “Frequent Recent Origination of Brain Genes Shaped the Evolution of Foraging Behavior in Drosophila.” Cell Reports 1, no. 2 (February 2012): 118–132.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorChen, Sidien_US
dc.relation.journalCell Reportsen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsChen, Sidi; Spletter, Maria; Ni, Xiaochun; White, Kevin P.; Luo, Liqun; Long, Manyuanen_US
mit.licensePUBLISHER_CCen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record