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dc.contributor.authorGanesh, Suma
dc.contributor.authorArora, Priyanka
dc.contributor.authorSethi, Sumita
dc.contributor.authorGandhi, Tapan Kumar
dc.contributor.authorKalia, Amy Ashwin
dc.contributor.authorChatterjee, Garga
dc.contributor.authorSinha, Pawan
dc.date.accessioned2016-05-16T12:49:49Z
dc.date.available2016-05-16T12:49:49Z
dc.date.issued2014-05
dc.date.submitted2014-05
dc.identifier.issn0007-1161
dc.identifier.urihttp://hdl.handle.net/1721.1/102504
dc.description.abstractBackground Cataracts are a major cause of childhood blindness globally. Although surgically treatable, it is unclear whether children would benefit from such interventions beyond the first few years of life, which are believed to constitute ‘critical’ periods for visual development. Aims To study visual acuity outcomes after late treatment of early-onset cataracts and also to determine whether there are longitudinal changes in postoperative acuity. Methods We identified 53 children with dense cataracts with an onset within the first half-year after birth through a survey of over 20 000 rural children in India. All had accompanying nystagmus and were older than 8 years of age at the time of treatment. They underwent bilateral cataract surgery and intraocular lens implantation. We then assessed their best-corrected visual acuity 6 weeks and 6 months after surgery. Results 48 children from the pool of 53 showed improvement in their visual acuity after surgery. Our longitudinal assessments demonstrated further improvements in visual acuity for the majority of these children proceeding from the 6-week to 6-month assessment. Interestingly, older children in our subject pool did not differ significantly from the younger ones in the extent of improvement they exhibit. Conclusions and relevance Our results demonstrate that not only can significant vision be acquired until late in childhood, but that neural processes underlying even basic aspects of vision like resolution acuity remain malleable until at least adolescence. These data argue for the provision of cataract treatment to all children, irrespective of their age.en_US
dc.description.sponsorshipNational Eye Institute (Grant R01EY020517)en_US
dc.description.sponsorshipJames S. McDonnell Foundationen_US
dc.language.isoen_US
dc.publisherBMJ Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1136/bjophthalmol-2013-304475en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleResults of late surgical intervention in children with early-onset bilateral cataractsen_US
dc.typeArticleen_US
dc.identifier.citationGanesh, S., P. Arora, S. Sethi, T. K. Gandhi, A. Kalia, G. Chatterjee, and P. Sinha. “Results of Late Surgical Intervention in Children with Early-Onset Bilateral Cataracts.” British Journal of Ophthalmology 98, no. 10 (October 1, 2014): 1424–28.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.mitauthorGandhi, Tapan Kumaren_US
dc.contributor.mitauthorKalia, Amy Ashwinen_US
dc.contributor.mitauthorChatterjee, Gargaen_US
dc.contributor.mitauthorSinha, Pawanen_US
dc.relation.journalBritish Journal of Ophthalmologyen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsGanesh, S.; Arora, P.; Sethi, S.; Gandhi, T. K.; Kalia, A.; Chatterjee, G.; Sinha, P.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-8259-7079
dc.identifier.orcidhttps://orcid.org/0000-0002-5886-9003
mit.licenseOPEN_ACCESS_POLICYen_US


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