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dc.contributor.authorFranses, Joseph W.
dc.contributor.authorEdelman, Elazer R.
dc.date.accessioned2016-05-22T19:10:21Z
dc.date.available2016-05-22T19:10:21Z
dc.date.issued2011-12
dc.date.submitted2011-08
dc.identifier.issn0008-5472
dc.identifier.issn1538-7445
dc.identifier.urihttp://hdl.handle.net/1721.1/102573
dc.description.abstractAlthough the roles of endothelial cells in cancer have primarily been considered to be related to tumor perfusion, the emerging appreciation of “angiocrine” regulation adds stromal regulatory capabilities to the expanding list of endothelial functions in tumors. We posit that an understanding of the state-dependent paracrine regulatory paradigms established in vascular disease and repair will be critical for a deep understanding of tumor biology, as endothelial cells regulate diverse processes in all vascularized tissues. Here, we outline the historical developments that led to the appreciation of the paracrine regulatory functions of endothelial cells, summarize classical views of blood vessels and stroma in cancer, and attempt to merge these ideas to include the stromal regulatory endothelial cell as a critical regulator of cancer. The notion of the endothelial cell as a biochemical regulator of cancer state in constant dynamic balance with its tumor could impact diagnosis, prognosis, and treatment of cancer. Such concepts might well explain the mixed results from antiangiogenic cancer therapeutics and how certain drugs that improve vascular health correlate with improved cancer prognosis.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (R01 GM-49039)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.). Medical Scientist Training Programen_US
dc.language.isoen_US
dc.publisherAmerican Association for Cancer Researchen_US
dc.relation.isversionofhttp://dx.doi.org/10.1158/0008-5472.can-11-1718en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleThe Evolution of Endothelial Regulatory Paradigms in Cancer Biology and Vascular Repairen_US
dc.typeArticleen_US
dc.identifier.citationFranses, J. W., and E. R. Edelman. “The Evolution of Endothelial Regulatory Paradigms in Cancer Biology and Vascular Repair.” Cancer Research 71, no. 24 (December 15, 2011): 7339–44.en_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.mitauthorFranses, Joseph W.en_US
dc.contributor.mitauthorEdelman, Elazer R.en_US
dc.relation.journalCancer Researchen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsFranses, J. W.; Edelman, E. R.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-7832-7156
mit.licenseOPEN_ACCESS_POLICYen_US


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