Analysis and control of contagion processes on networks

Abstract

We consider the propagation of a contagion process ("epidemic") on a network and study the problem of dynamically allocating a fixed curing budget to the nodes of the graph, at each time instant. We provide a dynamic policy for the rapid containment of a contagion process modeled as an SIS epidemic on a bounded degree undirected graph with n nodes. We show that if the budget r of curing resources available at each time is Q(W), where W is the CutWidth of the graph, and also of order [omega](log n), then the expected time until the extinction of the epidemic is of order O(n/r), which is within a constant factor from optimal, as well as sublinear in the number of nodes. Furthermore, if the CutWidth increases sublinearly with n, a sublinear expected time to extinction is possible with only a sublinearly increasing budget r. In contrast, we provide a lower bound on the expected time to extinction under any such dynamic allocation policy, for bounded degree graphs, in terms of a combinatorial quantity that we call the resistance of the set of initially infected nodes, the available budget, and the number of nodes n. Specifically, we consider the case of bounded degree graphs, with the resistance growing linearly in n. We show that if the curing budget is less than a certain multiple of the resistance, then the expected time to extinction grows exponentially with n. As a corollary, if all nodes are initially infected and the CutWidth of the graph grows linearly in n, while the curing budget is less than a certain multiple of the CutWidth, then the expected time to extinction grows exponentially in n. The combination of these two results establishes a fairly sharp phase transition on the expected time to extinction (sublinear versus exponential) based on the relation between the CutWidth and the curing budget. Finally, in the empirical part of the thesis, we analyze data on the evolution and propagation of influenza across the United States and discover that compartmental epidemic models enriched with environment dependent terms have fair prediction accuracy, and that the effect of inter-state traveling is negligible compared to the effect of intra-state contacts.