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dc.contributor.authorDiodato, Assunta
dc.contributor.authorRuinart de Brimont, Marion
dc.contributor.authorDerian, Nicolas
dc.contributor.authorPerrin, Sandrine
dc.contributor.authorPouch, Juliette
dc.contributor.authorKlatzmann, David
dc.contributor.authorGarel, Sonia
dc.contributor.authorFleischmann, Alexander
dc.contributor.authorYim, Yeong Shin
dc.contributor.authorChoi, Bohyun Gloria
dc.date.accessioned2016-12-12T20:10:30Z
dc.date.available2016-12-12T20:10:30Z
dc.date.issued2016-07
dc.date.submitted2015-09
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/1721.1/105796
dc.description.abstractThe ability to target subclasses of neurons with defined connectivity is crucial for uncovering neural circuit functions. The olfactory (piriform) cortex is thought to generate odour percepts and memories, and odour information encoded in piriform is routed to target brain areas involved in multimodal sensory integration, cognition and motor control. However, it remains unknown if piriform outputs are spatially organized, and if distinct output channels are delineated by different gene expression patterns. Here we identify genes selectively expressed in different layers of the piriform cortex. Neural tracing experiments reveal that these layer-specific piriform genes mark different subclasses of neurons, which project to distinct target areas. Interestingly, these molecular signatures of connectivity are maintained in reeler mutant mice, in which neural positioning is scrambled. These results reveal that a predictive link between a neuron’s molecular identity and connectivity in this cortical circuit is determined independent of its spatial position.en_US
dc.language.isoen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/ncomms12238en_US
dc.rightsCreative Commons Attribution 4.0 International Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceNatureen_US
dc.titleMolecular signatures of neural connectivity in the olfactory cortexen_US
dc.typeArticleen_US
dc.identifier.citationDiodato, Assunta et al. “Molecular Signatures of Neural Connectivity in the Olfactory Cortex.” Nature Communications 7 (2016): 12238.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.departmentMcGovern Institute for Brain Research at MITen_US
dc.contributor.mitauthorYim, Yeong Shin
dc.contributor.mitauthorChoi, Bohyun Gloria
dc.relation.journalNature Communicationsen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsDiodato, Assunta; Ruinart de Brimont, Marion; Yim, Yeong Shin; Derian, Nicolas; Perrin, Sandrine; Pouch, Juliette; Klatzmann, David; Garel, Sonia; Choi, Gloria B; Fleischmann, Alexanderen_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0001-9196-7302
dc.identifier.orcidhttps://orcid.org/0000-0003-4050-8338
mit.licensePUBLISHER_CCen_US


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