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dc.contributor.advisorDirk R. Englund.en_US
dc.contributor.authorAnubhav Sinha, Anubhav, M. Eng. Massachusetts Institute of Technologyen_US
dc.contributor.otherMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Science.en_US
dc.date.accessioned2017-01-12T18:33:48Z
dc.date.available2017-01-12T18:33:48Z
dc.date.copyright2015en_US
dc.date.issued2015en_US
dc.identifier.urihttp://hdl.handle.net/1721.1/106445
dc.descriptionThesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2015.en_US
dc.descriptionCataloged from PDF version of thesis.en_US
dc.descriptionIncludes bibliographical references (pages 69-77).en_US
dc.description.abstractThe nitrogen vacancy center (NV) in diamond hosts unique optical properties that allows it to be used for sensing magnetic fields, electric fields, and temperature. In addition, the photostability of the NV center and the biocompatibility of diamond suggests the utility of the NV center for biosensing. The dependence of the charge state of the NV center on the local electrochemical environment suggests that the NV center could be used as an optical sensor for electrophysiology. In this thesis, a platform to evaluate the utility of the NV center for voltage sensing is established. First, an electrophysiology setup is built and characterized on HEK293 cells. The setup adds functionality to a home built microscope so that cells can be electrically controlled while simultaneously observing the fluorescence. Second, the staining of neurons with hydrogen-terminated nanodiamonds (NDs) with NV centers is improved. Together, the improved staining of neurons with nanodiamonds along with using the electrophysiology setup to observe modulation forms a platform for future study of the NV center as a voltage sensor.en_US
dc.description.statementofresponsibilityby Anubhav Sinha.en_US
dc.format.extent77 pagesen_US
dc.language.isoengen_US
dc.publisherMassachusetts Institute of Technologyen_US
dc.rightsM.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.en_US
dc.rights.urihttp://dspace.mit.edu/handle/1721.1/7582en_US
dc.subjectElectrical Engineering and Computer Science.en_US
dc.titleDevelopment of a platform for sensing cellular electrical activity using nitrogen vacancy centers in nanodiamondsen_US
dc.typeThesisen_US
dc.description.degreeM. Eng.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
dc.identifier.oclc967346739en_US


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