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Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn’s Disease Phenotypes

Author(s)
Taleban, Sasha; Singh, Prashant; Yajnik, Vijay; Khalili, Hamed; Stewart, Kathleen O.; Li, Darrick K.; Pardi, Darrell S.; Sturgeon, Holly C.; Ananthakrishnan, Ashwin N.; Xavier, Ramnik Joseph; ... Show more Show less
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Abstract
Background Clinical activity and quality of life (QOL) indices assess disease activity in Crohn’s disease (CD) and ulcerative colitis (UC). However, a paucity of data exists on the validity of these indices according to disease characteristics. Aims To examine the correlation between QOL and clinical activity indices and endoscopic disease activity according to disease characteristics. Methods We used a prospective registry to identify CD and UC patients ≥18 years old with available information on Short Inflammatory Bowel Disease Questionnaire scores (SIBDQ), Harvey–Bradshaw Index (HBI) and simple endoscopic scores for CD (SES-CD), and Simple Clinical Colitis Activity Index (SCCAI) and Mayo endoscopic score for UC. We used Spearman rank correlations to calculate correlations between indices and Fisher transformation to compare correlations across disease characteristics. Results Among 282 CD patients, we observed poor correlation between clinical activity and QOL indices to SES-CD with no differences in correlation according to disease characteristics. Conversely, among 226 UC patients, clinical activity and QOL had good correlation to Mayo endoscopic score (r = 0.55 and −0.56, respectively) with better correlations observed with left-sided versus extensive colitis (r = 0.73 vs. 0.45, p = 0.005) and shorter duration of disease (r = 0.61 vs. 0.37, p = 0.04). Conclusions Our data suggest good correlation between SCCAI and endoscopic disease activity in UC, particularly in left-sided disease. Poor correlations between HBI or SIBDQ and SES-CD appear to be consistent across different disease phenotypes.
Date issued
2016-05
URI
http://hdl.handle.net/1721.1/107455
Department
Institute for Medical Engineering and Science
Journal
Digestive Diseases and Sciences
Publisher
Springer US
Citation
Taleban, Sasha, Kathleen O. Stewart, Darrick K. Li, Prashant Singh, Darrell S. Pardi, Holly C. Sturgeon, Vijay Yajnik, Ramnik J. Xavier, Ashwin N. Ananthakrishnan, and Hamed Khalili. “Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn’s Disease Phenotypes.” Digestive Diseases and Sciences 61, no. 9 (May 3, 2016): 2627–2635.
Version: Author's final manuscript
ISSN
0163-2116
1573-2568

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