Single-Cell Migration in Complex Microenvironments: Mechanics and Signaling Dynamics
Author(s)Mak, Michael; Spill, Fabian; Kamm, Roger Dale; Zaman, Muhammad
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Cells are highly dynamic and mechanical automata powered by molecular motors that respond to external cues. Intracellular signaling pathways, either chemical or mechanical, can be activated and spatially coordinated to induce polarized cell states and directional migration. Physiologically, cells navigate through complex microenvironments, typically in three-dimensional (3D) fibrillar networks. In diseases, such as metastatic cancer, they invade across physiological barriers and remodel their local environments through force, matrix degradation, synthesis, and reorganization. Important external factors such as dimensionality, confinement, topographical cues, stiffness, and flow impact the behavior of migrating cells and can each regulate motility. Here, we review recent progress in our understanding of single-cell migration in complex microenvironments.
DepartmentMassachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Mechanical Engineering
Journal of Biomechanical Engineering
Mak, Michael, Fabian Spill, Roger D. Kamm, and Muhammad H. Zaman. “Single-Cell Migration in Complex Microenvironments: Mechanics and Signaling Dynamics.” Journal of Biomechanical Engineering 138, no. 2 (January 27, 2016): 021004.
Final published version