MIT Libraries homeMIT Libraries logoDSpace@MIT

MIT
View Item 
  • DSpace@MIT Home
  • MIT Libraries
  • MIT Theses
  • Theses - Dept. of Chemistry
  • Chemistry - Ph.D. / Sc.D.
  • View Item
  • DSpace@MIT Home
  • MIT Libraries
  • MIT Theses
  • Theses - Dept. of Chemistry
  • Chemistry - Ph.D. / Sc.D.
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Studies toward the total syntheses of tamulamides A and B

Author(s)
Kelley, Elizabeth H. (Elizabeth Helen)
Thumbnail
DownloadFull printable version (19.05Mb)
Other Contributors
Massachusetts Institute of Technology. Department of Chemistry.
Advisor
Timothy F. Jamison.
Terms of use
MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission. http://dspace.mit.edu/handle/1721.1/7582
Metadata
Show full item record
Abstract
Progress toward the total syntheses of tamulamides A and B, two of the more recently isolated members of the marine ladder polyether family of natural products, is described. The tricyclic cores of the both the ABC fragment and the EFG fragment have been achieved. The fused tetrahydrofuran triad core of the ABC fragment has been synthesized via a base-mediated diepoxide cascade. The challenging 6,7,6 framework of the EFG fragment has been achieved through an intramolecular reductive cyclization reaction. With successful routes to the ABC and EFG cores in hand, current work is focused on elaboration of these intermediates to the desired Wittig coupling partners en route to the first total syntheses of tamulamides A and B ... [diagrams].
Description
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2017.
 
Cataloged from PDF version of thesis.
 
Includes bibliographical references.
 
Date issued
2017
URI
http://hdl.handle.net/1721.1/109676
Department
Massachusetts Institute of Technology. Department of Chemistry.
Publisher
Massachusetts Institute of Technology
Keywords
Chemistry.

Collections
  • Chemistry - Ph.D. / Sc.D.
  • Chemistry - Ph.D. / Sc.D.

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

Login

Statistics

OA StatisticsStatistics by CountryStatistics by Department
MIT Libraries homeMIT Libraries logo

Find us on

Twitter Facebook Instagram YouTube RSS

MIT Libraries navigation

SearchHours & locationsBorrow & requestResearch supportAbout us
PrivacyPermissionsAccessibility
MIT
Massachusetts Institute of Technology
Content created by the MIT Libraries, CC BY-NC unless otherwise noted. Notify us about copyright concerns.