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dc.contributor.authorSahay, Gaurav
dc.contributor.authorStewart, Martin P
dc.contributor.authorSharei, Armon Reza
dc.contributor.authorDing, Xiaoyun Sean
dc.contributor.authorLanger, Robert S
dc.contributor.authorJensen, Klavs F
dc.date.accessioned2017-08-04T13:47:16Z
dc.date.available2017-08-04T13:47:16Z
dc.date.issued2016-10
dc.date.submitted2015-03
dc.identifier.issn0028-0836
dc.identifier.issn1476-4687
dc.identifier.urihttp://hdl.handle.net/1721.1/110923
dc.description.abstractIntracellular delivery of materials has become a critical component of genome-editing approaches, ex vivo cell-based therapies, and a diversity of fundamental research applications. Limitations of current technologies motivate development of next-generation systems that can deliver a broad variety of cargo to diverse cell types. Here we review in vitro and ex vivo intracellular delivery approaches with a focus on mechanisms, challenges and opportunities. In particular, we emphasize membrane-disruption-based delivery methods and the transformative role of nanotechnology, microfluidics and laboratory-on-chip technology in advancing the field.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (R01GM101420-01A1)en_US
dc.language.isoen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/nature19764en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceProf. Jensen via Erja Kajosaloen_US
dc.titleIn vitro and ex vivo strategies for intracellular deliveryen_US
dc.typeArticleen_US
dc.identifier.citationStewart, Martin P.; Sharei, Armon; Ding, Xiaoyun et al. “In Vitro and Ex Vivo Strategies for Intracellular Delivery.” Nature 538, 7624 (October 2016): 183–192 © 2016 Macmillan Publishers Limited, part of Springer Natureen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.approverJensen, Klavs F.en_US
dc.contributor.mitauthorStewart, Martin P
dc.contributor.mitauthorSharei, Armon Reza
dc.contributor.mitauthorDing, Xiaoyun Sean
dc.contributor.mitauthorLanger, Robert S
dc.contributor.mitauthorJensen, Klavs F
dc.relation.journalNatureen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsStewart, Martin P.; Sharei, Armon; Ding, Xiaoyun; Sahay, Gaurav; Langer, Robert; Jensen, Klavs F.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-4112-6622
dc.identifier.orcidhttps://orcid.org/0000-0003-4252-9335
dc.identifier.orcidhttps://orcid.org/0000-0003-4255-0492
dc.identifier.orcidhttps://orcid.org/0000-0001-7192-580X
mit.licensePUBLISHER_POLICYen_US


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