Synthetic biology platform technologies for antimicrobial applications
Author(s)Braff, Dana; Shis, David Liu; Collins, James J.
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The growing prevalence of antibiotic resistance calls for new approaches in the development of antimicrobial therapeutics. Likewise, improved diagnostic measures are essential in guiding the application of targeted therapies and preventing the evolution of therapeutic resistance. Discovery platforms are also needed to form new treatment strategies and identify novel antimicrobial agents. By applying engineering principles to molecular biology, synthetic biologists have developed platforms that improve upon, supplement, and will perhaps supplant traditional broad-spectrum antibiotics. Efforts in engineering bacteriophages and synthetic probiotics demonstrate targeted antimicrobial approaches that can be fine-tuned using synthetic biology-derived principles. Further, the development of paper-based, cell-free expression systems holds promise in promoting the clinical translation of molecular biology tools for diagnostic purposes. In this review, we highlight emerging synthetic biology platform technologies that are geared toward the generation of new antimicrobial therapies, diagnostics, and discovery channels.
DepartmentInstitute for Medical Engineering and Science; MIT Synthetic Biology Center; Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Biological Engineering
Advanced Drug Delivery Reviews
Braff, Dana et al. “Synthetic Biology Platform Technologies for Antimicrobial Applications.” Advanced Drug Delivery Reviews 105 (October 2016): 35–43 © 2016 Elsevier B.V.
Author's final manuscript