dc.contributor.author | Rocks, Jason W. | |
dc.contributor.author | Pashine, Nidhi | |
dc.contributor.author | Bischofberger, Irmgard | |
dc.contributor.author | Goodrich, Carl P. | |
dc.contributor.author | Liu, Andrea J. | |
dc.contributor.author | Nagel, Sidney R. | |
dc.date.accessioned | 2017-11-17T15:58:37Z | |
dc.date.available | 2017-11-17T15:58:37Z | |
dc.date.issued | 2017-02 | |
dc.date.submitted | 2016-07 | |
dc.identifier.issn | 0027-8424 | |
dc.identifier.issn | 1091-6490 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/112223 | |
dc.description.abstract | Recent advances in designing metamaterials have demonstrated that global mechanical properties of disordered spring networks can be tuned by selectively modifying only a small subset of bonds. Here, using a computationally efficient approach, we extend this idea to tune more general properties of networks. With nearly complete success, we are able to produce a strain between any two target nodes in a network in response to an applied source strain on any other pair of nodes by removing only ∼1% of the bonds. We are also able to control multiple pairs of target nodes, each with a different individual response, from a single source, and to tune multiple independent source/target responses simultaneously into a network. We have fabricated physical networks in macroscopic 2D and 3D systems that exhibit these responses. This work is inspired by the long-range coupled conformational changes that constitute allosteric function in proteins. The fact that allostery is a common means for regulation in biological molecules suggests that it is a relatively easy property to develop through evolution. In analogy, our results show that long-range coupled mechanical responses are similarly easy to achieve in disordered networks. | en_US |
dc.publisher | National Academy of Sciences (U.S.) | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1073/pnas.1612139114 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | PNAS | en_US |
dc.title | Designing allostery-inspired response in mechanical networks | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Rocks, Jason W. et al. “Designing Allostery-Inspired Response in Mechanical Networks.” Proceedings of the National Academy of Sciences 114, 10 (February 2017): 2520–2525 © 2017 National Academy of Sciences | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Mechanical Engineering | en_US |
dc.contributor.mitauthor | Bischofberger, Irmgard | |
dc.relation.journal | Proceedings of the National Academy of Sciences | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dc.date.updated | 2017-10-30T19:25:56Z | |
dspace.orderedauthors | Rocks, Jason W.; Pashine, Nidhi; Bischofberger, Irmgard; Goodrich, Carl P.; Liu, Andrea J.; Nagel, Sidney R. | en_US |
dspace.embargo.terms | N | en_US |
mit.license | PUBLISHER_POLICY | en_US |