Studies on the total synthesis of gymnocin B

Author(s)
Sittihan, Satapanawat
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Massachusetts Institute of Technology. Department of Chemistry.
Advisor
Timothy F. Jamison.
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Abstract
Progress toward the biomimetic total synthesis of gymnocin B is described. Synthesis of the ABCDEFGH fragment has been completed in 30 steps longest linear sequence, using three different types of epoxide-opening cascades and one fragment coupling. Synthesis of the KLMNO fragment has been completed in 27 steps longest linear sequence, using one epoxide-opening cascade and one fragment coupling. The completion plan of gymnocin B is also detailed. [chemical formulas]
Description
Thesis: Ph. D. in Organic Chemistry, Massachusetts Institute of Technology, Department of Chemistry, 2017.
 
Cataloged from PDF version of thesis.
 
Includes bibliographical references.
 
Date issued
2017
URI
http://hdl.handle.net/1721.1/112442
Department
Massachusetts Institute of Technology. Department of Chemistry
Publisher
Massachusetts Institute of Technology
Keywords
Chemistry.
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