Design of PolyMOCs and the synthesis of crosslinkers for the BASP platform
Name
1008965483-MIT.pdf
Description
Full printable version
Size
2.79 MB
Format
Adobe PDF
Checksum (MD5)
bfcf9e957c88ab52c26bbab17749aee5
Author(s)
Park, Jiwon Victoria
Advisor(s)
Jeremiah A. Johnson.
Date Issued
2017
Publisher
Massachusetts Institute of Technology
Abstract
In Chapter 1, two stepwise assembly strategies for the integration of metal-organic cages (MOCs) into polymers were explored. The first strategy creates Block Co-PolyMOCs (BCPMOCs), which feature the integration of MOCs into block copolymers (BCPs). In the first assembly step, BCPs functionalized with a bispyridyl ligand on the chain end undergo Pd induced MOC assembly. In the second step, microphase separation of BCPs is induced, introducing a physical cross-link between the star polymers and producing the desired BCPMOC networks in the bulk or gel state. In the second strategy, another orthogonal interaction is explored to create a different type of polyMOC. In this case, poly(methyl acrylate) (PMA) homopolymers are synthesized from initiators featuring a diene or dienophile on one end and functionalized with a bispyridyl ligand on the other end. Diels-Alder (DA) cycloaddition is used in the second step to create a polyMOC network. Given the functional diversity of MOCs, both strategies should enable access to materials with a wide range of properties and applications. Chapter 2 outlines the synthesis of norbornene macromonomers (MMs) with varying anchor groups and crosslinkers that are stimuli-sensitive for the brush-arm star polymer (BASP) drug delivery platform. Variation of MM anchor groups modifies the rate of propagation of ring-opening metastasis polymerization (ROMP), while the design of crosslinkers that are acid- and photo-labile contributes to the expansion of a wide-ranging library of crosslinkers for drug loading and release. The brush-first ROMP polymerization strategy allows for the synthesis of BASPs for single drug or multiple drug combinations.
Description
Thesis: S.B., Massachusetts Institute of Technology, Department of Chemistry, 2017.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 33-34).
Subjects
Chemistry.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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