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Evaluation of predictive computational modelling in biologic formulation development

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dc.contributor.advisor Collin Stultz, Roger Kamm, and Thomas Roemer. en_US
dc.contributor.author Jayakumar, Jayanthi en_US
dc.contributor.other Leaders for Global Operations Program. en_US
dc.date.accessioned 2017-12-05T19:15:04Z
dc.date.available 2017-12-05T19:15:04Z
dc.date.copyright 2017 en_US
dc.date.issued 2017 en_US
dc.identifier.uri http://hdl.handle.net/1721.1/112488
dc.description Thesis: M.B.A., Massachusetts Institute of Technology, Sloan School of Management, in conjunction with the Leaders for Global Operations Program at MIT, 2017. en_US
dc.description Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, in conjunction with the Leaders for Global Operations Program at MIT, 2017. en_US
dc.description Cataloged from PDF version of thesis. en_US
dc.description Includes bibliographical references (pages 81-87). en_US
dc.description.abstract Computational modelling has completely redefined the experimentation process in many industries, allowing large sets of design concepts to be tested quickly and cheaply very early in the innovation process. Harnessing the power of computational modelling for protein drug formulation has numerous, currently unrealized, benefits. This project aims to be the first step in the development of a high throughput predictive computational model to screen for excipients that would decrease protein aggregation in solution and thus increase its stability and enable clinical effectiveness. Protein drug formulation currently relies heavily on empirical evidence from wet-lab experiments and personal experience. During the biologic drug development process, proteins that target specific disease pathways are identified, developed, isolated, and purified. Scientists then conduct a series of wet-lab experiments to identify the optimal formulation that will allow the protein to be used as a drug therapy. A critical part of formulation development is the identification of inactive ingredients called excipients that perform various important functions including prevention of protein aggregation. Despite their critical role in enabling proteins to be effective therapies, very little is understood about excipient-protein interaction. Furthermore, often a limited set of compounds are tested for their use as excipients since wet-lab experiments are expensive and time consuming. This project accomplishes the following goals: ** Identification of databases of compounds that could be used as excipients in biologic formulation; ** Development of a high throughput method to computationally model a target protein and 247 potential excipients; ** Evaluation of potential relationship between computational output and wet-lab results based onxperimentation with 32 of the 247 excipients; ** Recommendations on next steps that include feedback on types of proteins and excipients to be tested for the validation of the method developed in this project. en_US
dc.description.statementofresponsibility by Jayanthi Jayakumar. en_US
dc.format.extent 97 pages en_US
dc.language.iso eng en_US
dc.publisher Massachusetts Institute of Technology en_US
dc.rights MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission. en_US
dc.rights.uri http://dspace.mit.edu/handle/1721.1/7582 en_US
dc.subject Sloan School of Management. en_US
dc.subject Mechanical Engineering. en_US
dc.subject Leaders for Global Operations Program. en_US
dc.title Evaluation of predictive computational modelling in biologic formulation development en_US
dc.type Thesis en_US
dc.description.degree M.B.A. en_US
dc.description.degree S.M. en_US
dc.contributor.department Sloan School of Management. en_US
dc.contributor.department Massachusetts Institute of Technology. Department of Mechanical Engineering. en_US
dc.contributor.department Leaders for Global Operations Program. en_US
dc.identifier.oclc 1011506002 en_US


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