Show simple item record

dc.contributor.authorHeidenreich, Matthias
dc.contributor.authorZhang, Feng
dc.date.accessioned2017-12-13T16:18:11Z
dc.date.available2017-12-13T16:18:11Z
dc.date.issued2015-12
dc.identifier.issn1471-003X
dc.identifier.issn1471-0048
dc.identifier.urihttp://hdl.handle.net/1721.1/112734
dc.description.abstractGenome-editing tools, and in particular those based on CRISPR-Cas (clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated protein) systems, are accelerating the pace of biological research and enabling targeted genetic interrogation in almost any organism and cell type. These tools have opened the door to the development of new model systems for studying the complexity of the nervous system, including animal models and stem cell-derived in vitro models. Precise and efficient gene editing using CRISPR-Cas systems has the potential to advance both basic and translational neuroscience research.en_US
dc.description.sponsorshipNational Institute of Mental Health (U.S.) (Grant 5DP1-MH100706)en_US
dc.description.sponsorshipNational Institute of Mental Health (U.S.) (Grant 1R01-MH110049)en_US
dc.description.sponsorshipNational Institute of Diabetes and Digestive and Kidney Diseases (U.S.) (Grant 5R01DK097768-03)en_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/nrn.2015.2en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleApplications of CRISPR–Cas systems in neuroscienceen_US
dc.typeArticleen_US
dc.identifier.citationHeidenreich, Matthias and Zhang, Feng. "Applications of CRISPR–Cas systems in neuroscience." Nature Reviews Neuroscience 17 (January 2016): 36-44 © 2016 Macmillan Publishers Limiteden_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.departmentMcGovern Institute for Brain Research at MITen_US
dc.contributor.mitauthorHeidenreich, Matthias
dc.contributor.mitauthorZhang, Feng
dc.relation.journalNature Reviews Neuroscienceen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2017-12-12T19:31:10Z
dspace.orderedauthorsHeidenreich, Matthias; Zhang, Fengen_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-2782-2509
mit.licenseOPEN_ACCESS_POLICYen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record