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Single-cell transcriptomics of the mouse thalamic reticular nucleus

Author(s)
Li, Taibo,M. Eng.Massachusetts Institute of Technology.
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Alternative title
Single-cell transcriptomics of the mouse TRN
Other Contributors
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science.
Advisor
Guoping Feng and Kasper Lage.
Terms of use
MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission. http://dspace.mit.edu/handle/1721.1/7582
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Abstract
The thalamic reticular nucleus (TRN) is strategically located at the interface between the cortex and the thalamus, and plays a key role in regulating thalamo-cortical interactions. Current understanding of TRN neurobiology has been limited due to the lack of a comprehensive survey of TRN heterogeneity. In this thesis, I developed an integrative computational framework to analyze the single-nucleus RNA sequencing data of mouse TRN in a data-driven manner. By combining transcriptomic, genetic, and functional proteomic data, I discovered novel insights into the molecular mechanisms through which TRN regulates sensory gating, and suggested targeted follow-up experiments to validate these findings.
Description
Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2017
 
Cataloged from PDF version of thesis.
 
Includes bibliographical references (pages 44-49).
 
Date issued
2017
URI
http://hdl.handle.net/1721.1/113178
Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Publisher
Massachusetts Institute of Technology
Keywords
Electrical Engineering and Computer Science.

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