Single-cell transcriptomics of the mouse thalamic reticular nucleus
Author(s)Li, Taibo,M. Eng.Massachusetts Institute of Technology.
Single-cell transcriptomics of the mouse TRN
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science.
Guoping Feng and Kasper Lage.
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The thalamic reticular nucleus (TRN) is strategically located at the interface between the cortex and the thalamus, and plays a key role in regulating thalamo-cortical interactions. Current understanding of TRN neurobiology has been limited due to the lack of a comprehensive survey of TRN heterogeneity. In this thesis, I developed an integrative computational framework to analyze the single-nucleus RNA sequencing data of mouse TRN in a data-driven manner. By combining transcriptomic, genetic, and functional proteomic data, I discovered novel insights into the molecular mechanisms through which TRN regulates sensory gating, and suggested targeted follow-up experiments to validate these findings.
Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2017Cataloged from PDF version of thesis.Includes bibliographical references (pages 44-49).
DepartmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology
Electrical Engineering and Computer Science.