Spatial Charge Configuration Regulates Nanoparticle Transport and Binding Behavior In Vivo
Author(s)Fukumura, Dai; Jain, Rakesh K.; Han, Hee-Sun; Martin, John Daniel; Lee, Jungmin; Harris, Daniel Kelly; Bawendi, Moungi G; ... Show more Show less
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Detailed arrangements: A new set of zwitterionic quantum dots were synthesized and used to study the influence of microscopic charge arrangements on the in vivo behavior of nanoparticles. Experiments using cultured cells and live mice demonstrate that the microscopic arrangement of surface charges strongly influences nonspecific binding, clearance behavior, and in vivo transport of nanoparticles.
DepartmentMassachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Department of Chemistry; Massachusetts Institute of Technology. Department of Materials Science and Engineering
Angewandte Chemie International Edition
Han, Hee-Sun et al. “Spatial Charge Configuration Regulates Nanoparticle Transport and Binding Behavior In Vivo.” Angewandte Chemie International Edition 52, 5 (December 2012): 1414–1419 © 2013 WILEY-VCH Verlag GmbH & Co
Author's final manuscript