Spatial Charge Configuration Regulates Nanoparticle Transport and Binding Behavior In Vivo

Author(s)
Fukumura, Dai; Jain, Rakesh K.; Han, Hee-Sun; Martin, John Daniel; Lee, Jungmin; ... Show more
Thumbnail
Downloadnihms496482.pdf (1.861Mb)
OPEN_ACCESS_POLICY
Terms of use
Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/
Metadata
Show full item record
Abstract
Detailed arrangements: A new set of zwitterionic quantum dots were synthesized and used to study the influence of microscopic charge arrangements on the in vivo behavior of nanoparticles. Experiments using cultured cells and live mice demonstrate that the microscopic arrangement of surface charges strongly influences nonspecific binding, clearance behavior, and in vivo transport of nanoparticles.
Date issued
2013-01
URI
http://hdl.handle.net/1721.1/113196
Department
Massachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Department of Chemistry; Massachusetts Institute of Technology. Department of Materials Science and Engineering
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Han, Hee-Sun et al. “Spatial Charge Configuration Regulates Nanoparticle Transport and Binding Behavior In Vivo.” Angewandte Chemie International Edition 52, 5 (December 2012): 1414–1419 © 2013 WILEY-VCH Verlag GmbH & Co
Version: Author's final manuscript
ISSN
1433-7851
1521-3773
Collections