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dc.contributor.authorDolatshahi-Pirouz, Alireza
dc.contributor.authorNikkhah, Mehdi
dc.contributor.authorKolind, Kristian
dc.contributor.authorDokmeci, Mehmet R.
dc.contributor.authorKhademhosseini, Alireza
dc.date.accessioned2018-01-31T14:10:10Z
dc.date.available2018-01-31T14:10:10Z
dc.date.issued2011-06
dc.date.submitted2011-06
dc.identifier.issn2079-4983
dc.identifier.urihttp://hdl.handle.net/1721.1/113375
dc.description.abstractAs our population ages, there is a greater need for a suitable supply of engineered tissues to address a range of debilitating ailments. Stem cell based therapies are envisioned to meet this emerging need. Despite significant progress in controlling stem cell differentiation, it is still difficult to engineer human tissue constructs for transplantation. Recent advances in micro- and nanofabrication techniques have enabled the design of more biomimetic biomaterials that may be used to direct the fate of stem cells. These biomaterials could have a significant impact on the next generation of stem cell based therapies. Here, we highlight the recent progress made by micro- and nanoengineering techniques in the biomaterials field in the context of directing stem cell differentiation. Particular attention is given to the effect of surface topography, chemistry, mechanics and micro- and nanopatterns on the differentiation of embryonic, mesenchymal and neural stem cells. Keywords: micro- and nanotopography; microwells; microarrays; embryonic and adult stem cells; stem cell therapyen_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant HL092836)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant DE019024)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant EB008392)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant DE021468)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant AR05837)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant EB012597)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant HL099073)en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (Award DMR 0847287)en_US
dc.publisherMDPI AGen_US
dc.relation.isversionofhttp://dx.doi.org/10.3390/jfb2030088en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceMultidisciplinary Digital Publishing Instituteen_US
dc.titleMicro- and Nanoengineering Approaches to Control Stem Cell-Biomaterial Interactionsen_US
dc.typeArticleen_US
dc.identifier.citationDolatshahi-Pirouz, Alireza et al. "Micro- and Nanoengineering Approaches to Control Stem Cell-Biomaterial Interactions." Journal of Functional Biomaterials 2, 3 (June 2011): 88-106 © 2011 The Author(s)en_US
dc.contributor.departmentInstitute for Medical Engineering and Scienceen_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.mitauthorKhademhosseini, Alireza
dc.relation.journalJournal of Functional Biomaterialsen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2018-01-24T21:03:27Z
dspace.orderedauthorsDolatshahi-Pirouz, Alireza; Nikkhah, Mehdi; Kolind, Kristian; Dokmeci, Mehmet R.; Khademhosseini, Alien_US
dspace.embargo.termsNen_US
mit.licensePUBLISHER_CCen_US


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