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dc.contributor.authorSwager, Timothy M
dc.date.accessioned2018-02-12T16:37:13Z
dc.date.available2018-02-12T16:37:13Z
dc.date.issued2017-01
dc.identifier.issn2374-7943
dc.identifier.issn2374-7951
dc.identifier.urihttp://hdl.handle.net/1721.1/113583
dc.description.abstractAn unintended consequence of our chemical innovations is the introduction of trace chemicals into our environment that are not necessarily directly toxic, but can impact nature. Mutations in animals/people can happen naturally, but perhaps in many cases human chemical ingenuity is to blame. Our motivations as chemists are honorable, and we have generated pesticides that help us to grow more food, agents to extract hydrocarbons from the earth, and durable materials that can be washed and reused in drinking and baby bottles. Functionally detecting these chemicals in our environment at trace levels, in real time, and in a cost-effective manner has been a challenge. Professor Matthew Francis and co-workers Ariel Furst and Alexander Hoepker have devised a powerful new method to detect suspect compounds known as endocrine disrupting chemicals. In this issue they report a novel assay that can functionally detect suspect compounds that bind to the estrogen receptor α. This approach involves direct electrical detection, which has the benefit of being readily interfaced with a number of existing platforms. Specifically, this team developed electrochemical impedance methods for the detection of endocrine disrupting compounds by using a novel sandwich scheme. Engineered Escherichia coli is produced that expresses the estrogen receptor α on its surface, and this structure behaves as a very large blocking scaffold that can restrict diffusion of ions to an electrode.en_US
dc.publisherAmerican Chemical Society (ACS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/ACSCENTSCI.7B00045en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceACSen_US
dc.titleImpedance for Endocrine Disruption Compoundsen_US
dc.typeArticleen_US
dc.identifier.citationSwager, Timothy M. “Impedance for Endocrine Disruption Compounds.” ACS Central Science 3, 2 (January 2017): 99–100 © 2017 American Chemical Societyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.mitauthorSwager, Timothy M
dc.relation.journalACS Central Scienceen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2018-02-08T17:38:46Z
dspace.orderedauthorsSwager, Timothy M.en_US
dspace.embargo.termsNen_US
mit.licensePUBLISHER_POLICYen_US


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