Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography
Author(s)
Huang, Qin; Mashimo, Hiroshi; Lee, Hsiang-Chieh; Ahsen, Osman Oguz; Liu, Jonathan Jaoshin; Tsai, Tsung-Han; Fujimoto, James G; ... Show more Show less
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Radiofrequency ablation (RFA) is widely used for the eradication of dysplasia and the treatment of early stage esophageal carcinoma in patients with Barrett's esophagus (BE). However, there are several factors, such as variation of BE epithelium (EP) thickness among individual patients and varying RFA catheter-tissue contact, which may compromise RFA efficacy. We used a high-speed optical coherence tomography (OCT) system to identify and monitor changes in the esophageal tissue architecture from RFA. Two different OCT imaging/RFA application protocols were performed using an ex vivo swine esophagus model: (1) post-RFA volumetric OCT imaging for quantitative analysis of the coagulum formation using RFA applications with different energy settings, and (2) M-mode OCT imaging for monitoring the dynamics of tissue architectural changes in real time during RFA application. Post-RFA volumetric OCT measurements showed an increase in the coagulum thickness with respect to the increasing RFA energies. Using a subset of the specimens, OCT measurements of coagulum and coagulum + residual EP thickness were shown to agree with histology, which accounted for specimen shrinkage during histological processing. In addition, we demonstrated the feasibility of OCT for real-time visualization of the architectural changes during RFA application with different energy settings. Results suggest feasibility of using OCT for RFA treatment planning and guidance.
Date issued
2017-07Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Massachusetts Institute of Technology. Research Laboratory of ElectronicsJournal
Journal of Biomedical Optics
Publisher
SPIE
Citation
Lee, Hsiang-Chieh et al. “Assessment of the Radiofrequency Ablation Dynamics of Esophageal Tissue with Optical Coherence Tomography.” Journal of Biomedical Optics 22, 7 (July 2017): 076001 © 2017 The Authors
Version: Final published version
ISSN
1083-3668
1560-2281