Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression
Author(s)Ye, Xin; Weinberg, Robert A
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The epithelial-mesenchymal transition (EMT) program has emerged as a central driver of tumor malignancy. Moreover, the recently uncovered link between passage through an EMT and acquisition of stem-like properties indicates that activation of the EMT programs serves as a major mechanism for generating cancer stem cells (CSCs); that is, a subpopulation of cancer cells that are responsible for initiating and propagating the disease. In this review, we summarize the evidence supporting the widespread involvement of the EMT program in tumor pathogenesis and attempt to rationalize the connection between the EMT program and acquisition of stem cell traits. We propose that epithelial-mesenchymal plasticity is likely controlled by multiple varients of the core EMT program, and foresee the need to resolve the various programs and the molecular mechanisms that underlie them.
DepartmentMassachusetts Institute of Technology. Department of Biology
Trends in Cell Biology
Ye, Xin, and Robert A. Weinberg. “Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression.” Trends in Cell Biology 25, no. 11 (November 2015): 675–686.
Author's final manuscript