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dc.contributor.advisorPolina Anikeeva.en_US
dc.contributor.authorPark, Seongjunen_US
dc.contributor.otherMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Science.en_US
dc.date.accessioned2018-09-17T15:56:54Z
dc.date.available2018-09-17T15:56:54Z
dc.date.copyright2018en_US
dc.date.issued2018en_US
dc.identifier.urihttp://hdl.handle.net/1721.1/118086
dc.descriptionThesis: Ph. D., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2018.en_US
dc.descriptionCataloged from PDF version of thesis.en_US
dc.descriptionIncludes bibliographical references (pages 161-174).en_US
dc.description.abstractNeurological disorders affect up to a billion people worldwide, and their socioeconomic burden is projected to increase as the population ages. However, our ability to understand and to treat neural disorders is currently limited by the lack of tools capable of interfacing with the brain over extended periods of time. This is hypothesized to stem from the mismatch in mechanical and chemical properties between the neural probes and the neural tissues, which leads to foreign body response and functional device failure due to tissue scarring in the probe vicinity. To address the challenge, I developed fiber-based bioelectronic devices integrating diverse modalities within a single platform using thermal drawing process (TDP). All-polymer or hydrogel integrated probes with optical, electrical, and fluidic capabilities were developed all within the 100-200 [mu]m diameter, which allowed one-step surgery to the mouse brain and spinal cord for optogenetic experiments. This probe also addressed the challenge of biocompatibility and enabled the recording isolated action potentials for 3 months. In addition, I applied TPD to produce biocompatible polymer-based neural scaffold with various geometries (round, rectangular, micro-grooved) and dimensions between 50-200 [mu]m. This allowed for investigation of the enhancement of neurite growth as a function of fiber parameters. We found that the topographical features and the narrow channels generally led to enhanced growth. This thesis illustrated a variety of applications of multifunctional fiber-based devices in neuroscience and neural engineering, which anticipated to enable basic studies of the nervous system and future treatment of neurological disorders.en_US
dc.description.statementofresponsibilityby Seongjun Park.en_US
dc.format.extent174 pagesen_US
dc.language.isoengen_US
dc.publisherMassachusetts Institute of Technologyen_US
dc.rightsMIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission.en_US
dc.rights.urihttp://dspace.mit.edu/handle/1721.1/7582en_US
dc.subjectElectrical Engineering and Computer Science.en_US
dc.titleMultifunctional fiber-based neural interfacesen_US
dc.typeThesisen_US
dc.description.degreePh. D.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
dc.identifier.oclc1052124004en_US


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