Active Manipulation of ECM Stiffness
Author(s)
Chen, Peter C. Y.
Herath, Sahan C. B.
Wang, Dong-an
Su, Kai
Liao, Kin
Asada, Haruhiko
Date Issued
June 2011
Journal
ASME 2011 Summer Bioengineering Conference, Parts A and B
Publisher
American Society of Mechanical Engineers
Citation
Chen, Peter C. Y., et al. “Active Manipulation of ECM Stiffness.” ASME 2011 Summer Bioengineering Conference, Parts A and B, 22-25 June, 2011, Farmington, Pennsylvania, ASME, 2011, p. 869. © 2011 by ASME
Version
Final published version
Abstract
The mechanical properties of the microstructures surrounding cells influence the behavior of cells in differentiation, proliferation, and apoptosis, etc. The stiffness of the extra-cellular microenvironment has been shown to be one such mechanical property. Studies reported in the literature concerning the stiffness of the extracellular microenvironment mainly sought to understand the scientific principles and mechanisms underlying its effect on cell-environment interaction. This paper describes an approach that achieves such manipulation, and reports experimental results that demonstrate the effectiveness of this proposed approach.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1115/SBC2011-53090
