MIT Libraries logoDSpace@MIT

MIT
View Item 
  • DSpace@MIT Home
  • MIT Libraries
  • MIT Theses
  • Undergraduate Theses
  • View Item
  • DSpace@MIT Home
  • MIT Libraries
  • MIT Theses
  • Undergraduate Theses
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Polymer synthesis for corona phase molecular recognition based on single-walled carbon nanotubes

Author(s)
Sun, Jessica H
Thumbnail
DownloadFull printable version (4.685Mb)
Other Contributors
Massachusetts Institute of Technology. Department of Materials Science and Engineering.
Advisor
Michael S. Strano.
Terms of use
MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission. http://dspace.mit.edu/handle/1721.1/7582
Metadata
Show full item record
Abstract
Current work within Strano Research Group shows that single-walled carbon nanotubes (SWNT) wrapped with methacrylic acid-styrene heteropolymer (MA-ST) can be used for specific corona phase molecular recognition (CoPhMoRe) of Vardenafil, a small molecule drug. This project is a follow-up study on viability of related polymers for CoPhMoRe sensing of five small molecule drugs: Fluticasone, Sumatriptan, Valacyclovir, Vardenafil, and Bupropion. Methacrylic acid-vinylphenylboronic acid (MA-VBA) heteropolymer and acrylic acid-styrene (AA-ST) heteropolymer were synthesized at different monomer ratios and chain lengths. These polymers were suspended with the carbon nanotubes and screened against the five drugs. The (12,1) chirality of MA-VBA-4 and (7,5) chirality of AA-ST-2 were found to be potential candidates for sensing of Fluticasone and Vardenafil respectively. However, MA-ST 8 remains as the superior choice for the specific sensing of Vardenafil.
Description
Thesis: S.B., Massachusetts Institute of Technology, Department of Materials Science and Engineering, 2018.
 
Cataloged from PDF version of thesis.
 
Includes bibliographical references (pages 32-34).
 
Date issued
2018
URI
http://hdl.handle.net/1721.1/119068
Department
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Publisher
Massachusetts Institute of Technology
Keywords
Materials Science and Engineering.

Collections
  • Undergraduate Theses

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

Login

Statistics

OA StatisticsStatistics by CountryStatistics by Department
MIT Libraries
PrivacyPermissionsAccessibilityContact us
MIT
Content created by the MIT Libraries, CC BY-NC unless otherwise noted. Notify us about copyright concerns.