Natural Products Containing ‘Rare’ Organophosphorus Functional Groups
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molecules-24-00866.pdf
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6.54 MB
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Adobe PDF
Checksum (MD5)
22d1dcc25e27396ba7eddb73ac9397ed
Author(s)
Bains, William
Petkowski, Janusz Jurand
Seager, Sara
Date Issued
February 2019
Journal
Molecules
Publisher
Multidisciplinary Digital Publishing Institute
Citation
Petkowski, Janusz, et al. “Natural Products Containing ‘Rare’ Organophosphorus Functional Groups.” Molecules, vol. 24, no. 5, Feb. 2019, p. 866.
Version
Final published version
Abstract
Phosphorous-containing molecules are essential constituents of all living cells. While the phosphate functional group is very common in small molecule natural products, nucleic acids, and as chemical modification in protein and peptides, phosphorous can form P-N (phosphoramidate), P-S (phosphorothioate), and P-C (e.g., phosphonate and phosphinate) linkages. While rare, these moieties play critical roles in many processes and in all forms of life. In this review we thoroughly categorize P-N, P-S, and P-C natural organophosphorus compounds. Information on biological source, biological activity, and biosynthesis is included, if known. This review also summarizes the role of phosphorylation on unusual amino acids in proteins (N- and S-phosphorylation) and reviews the natural phosphorothioate (P-S) and phosphoramidate (P-N) modifications of DNA and nucleotides with an emphasis on their role in the metabolism of the cell. We challenge the commonly held notion that nonphosphate organophosphorus functional groups are an oddity of biochemistry, with no central role in the metabolism of the cell. We postulate that the extent of utilization of some phosphorus groups by life, especially those containing P-N bonds, is likely severely underestimated and has been largely overlooked, mainly due to the technological limitations in their detection and analysis. Keywords: P–N bond; phosphoramidate; N-phosphorylation; P–S bond; phosphorothioate; S-phosphorylation; P–C bond; phosphonate; phosphinate; phosphine
MIT Department
Massachusetts Institute of Technology. Department of Aeronautics and Astronautics
Massachusetts Institute of Technology. Department of Earth, Atmospheric, and Planetary Sciences
Massachusetts Institute of Technology. Department of Physics
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.3390/molecules24050866
