Next-generation precision antimicrobials: towards personalized treatment of infectious diseases
Author(s)de la Fuente Nunez, Cesar; Torres, Marcelo D. T.; Mojica, Francisco J. M.; Lu, Timothy K
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Antibiotics started to be used almost 90 years ago to eradicate life-threatening infections. The urgency of the problem required rapid, broad-spectrum elimination of infectious agents. Since their initial discovery, these antimicrobials have saved millions of lives. However, they are not exempt from side effects, which include the indiscriminate disruption of the beneficial microbiota. Recent technological advances have enabled the development of antimicrobials that can selectively target a gene, a cellular process, or a microbe of choice. These strategies bring us a step closer to developing personalized therapies that exclusively remove disease-causing infectious agents. Here, we advocate the preservation of our beneficial microbes and provide an overview of promising alternatives to broad-spectrum antimicrobials. Specifically, we emphasize nucleic acid and peptide-based systems as a foundation for next-generation alternatives to antibiotics that do not challenge our microbiota and may help to mitigate the spread of resistance.
DepartmentMassachusetts Institute of Technology. Research Laboratory of Electronics; Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Current Opinion in Microbiology
" Next-generation precision antimicrobials: towards personalized treatment of infectious diseases." Current Opinion in Microbiology 37 (June 2017): 95-102 © 2017 Elsevier
Author's final manuscript