Enantioselective synthesis of pretomanid & investigations of Raman spectroscopy for through-tube monitoring of reactions
Author(s)Tran, Tho Huu.
Enantioselective synthesis of pretomanid and investigations of Raman spectroscopy for through-tube monitoring of reactions
Investigations of Raman spectroscopy for through-tube monitoring of reactions
Massachusetts Institute of Technology. Department of Chemistry.
Timothy F. Jamison.
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Chapter 1: Enantioselective Synthesis of Pretomanid [color illustrations] Pretomanid is a potential cornerstone active pharmaceutical ingredient for the treatment of tuberculosis (TB). It is found in several advanced clinical trials and can possibly treat all forms of TB. In this report, we discuss the development of a novel synthesis of pretomanid through a selective epoxide-opening cyclization and late-stage nitration. This route offers a new strategy to access the core of pretomanid and avoids the necessity of the explosive starting material. Chapter 2: Investigations of Raman Spectroscopy for Through-Tube Monitoring of Reactions [color illustrations] Continuous-flow chemistry has seen expansive growth and thus requires powerful new analytical techniques. The current commonly-used analytics involve inline analysis at a single point, which can hinder analysis. In this report, we demonstrate the utility of the MarqMetrix TouchRaman probe for reaction monitoring through a continuous-flow reactor. The reactions studied were ring-closing metathesis, benzyne generation, and ketene generation.
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2019Cataloged from PDF version of thesis.Includes bibliographical references.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Massachusetts Institute of Technology