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Microstimulation of primate neocortex targeting striosomes induces negative decision-making

Author(s)
Amemori, Satoko; Amemori, Ken-ichi; Yoshida, Tomoko; Papageorgiou, Georgios; Xu, Rui; Shimazu, Hideki; Desimone, Robert; Graybiel, Ann M; ... Show more Show less
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DownloadAmemori S et al (2019) Euro J Neurosci[1].pdf (4.011Mb)
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Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/
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Abstract
Affective judgment and decision-making are strongly modulated by the pregenual anterior cingulate (pACC) and caudal orbitofrontal (cOFC) cortical regions. By combining MRI-guided electrical microstimulation with viral tracing methods in non-human primates, we demonstrate that circumscribed pACC and cOFC microstimulation sites that induce negative decision-making preferentially project to striosomes in the anterior striatum. These results outline a behaviorally important circuit from pACC/cOFC to striosomes causally modulating decision-making under emotional conflict. Keywords: anterior cingulate cortex; approach–avoidance; microstimulation; orbitofrontal cortex; striatum
Date issued
2019-08
URI
https://hdl.handle.net/1721.1/123109
Department
McGovern Institute for Brain Research at MIT; Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Journal
European Journal of Neuroscience
Publisher
Wiley
Citation
Amemori, Satoko et al. "Microstimulation of primate neocortex targeting striosomes induces negative decision‐making." European Journal of Neuroscience (August 2019): 1-11 © 2019 Federation of European Neuroscience Societies
Version: Author's final manuscript
ISSN
0953-816X
1460-9568

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