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dc.contributor.authorRegev, Aviv
dc.date.accessioned2020-05-05T15:27:04Z
dc.date.available2020-05-05T15:27:04Z
dc.date.issued2019-04
dc.identifier.issn1534-5807
dc.identifier.urihttps://hdl.handle.net/1721.1/125012
dc.description.abstractSingle-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan. We discuss the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan.en_US
dc.language.isoen
dc.publisherElsevier BVen_US
dc.relation.isversionof10.1016/j.devcel.2019.03.001en_US
dc.rightsCreative Commons Attribution 4.0 International licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.sourceElsevieren_US
dc.subjectDevelopmental Biologyen_US
dc.titleThe Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolutionen_US
dc.typeArticleen_US
dc.identifier.citationTaylor, Deanne M. et al. “The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution.” Developmental Cell 49 (2019): 10-29 © 2019 The Author(s)en_US
dc.contributor.departmentDavid H. Koch Institute for Integrative Cancer Research at MITen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.relation.journalDevelopmental Cellen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2020-01-28T18:57:41Z
dspace.date.submission2020-01-28T18:57:44Z
mit.journal.volume49en_US
mit.journal.issue1en_US


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