“Inactive” ingredients in oral medications

Author(s)
Reker, Daniel; Blum, Steven M.; Steiger, Christoph Winfried Johannes; Anger, Kevin E.; Sommer, Jamie M.; ... Show more
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Abstract
Oral forms of medications contain "inactive" ingredients to enhance their physical properties. Using data analytics, we characterized the abundance and complexity of inactive ingredients in approved medications. A majority of medications contain ingredients that could cause adverse reactions, underscoring the need to maximize the tolerability and safety of medications and their inactive ingredients.
Date issued
2019-03
URI
https://hdl.handle.net/1721.1/125869
Department
Massachusetts Institute of Technology. Department of Mechanical Engineering; Koch Institute for Integrative Cancer Research at MIT
Journal
Science Translational Medicine
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Reker, Daniel et al. '"Inactive" ingredients in oral medications.' Science Translational Medicine 11, 483 (March 2019): eaau6753 © 2019 The Authors
Version: Author's final manuscript
ISSN
1946-6234
1946-6242
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