Modular continuous flow synthesis of imatinib and analogues
Author(s)Fu, Wai Chung; Jamison, Timothy F
MetadataShow full item record
A modular continuous flow synthesis of imatinib and analogues is reported. Structurally diverse imatinib analogues are rapidly generated using three readily available building blocks via a flow hydration/chemoselective C-N coupling sequence. The newly developed continuous flow hydration and amidation modules each exhibit a broad scope with good to excellent yields. Overall, the method described does not require solvent switches, in-line purifications, or packed-bed apparatuses due to the judicious manipulation of flow setups and solvent mixtures.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
American Chemical Society (ACS)
Fu, Wai Chung, and Timothy F. Jamison, "Modular continuous flow synthesis of imatinib and analogues." Organic Letters 21, 15 (July 2019): p. 6112-16 doi 10.1021/ACS.ORGLETT.9B02259 ©2019 Author(s)
Author's final manuscript