| dc.contributor.author | Fu, Wai Chung | |
| dc.contributor.author | Jamison, Timothy F | |
| dc.date.accessioned | 2020-06-23T19:37:48Z | |
| dc.date.available | 2020-06-23T19:37:48Z | |
| dc.date.issued | 2019-07 | |
| dc.identifier.issn | 1523-7052 | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/125954 | |
| dc.description.abstract | A modular continuous flow synthesis of imatinib and analogues is reported. Structurally diverse imatinib analogues are rapidly generated using three readily available building blocks via a flow hydration/chemoselective C-N coupling sequence. The newly developed continuous flow hydration and amidation modules each exhibit a broad scope with good to excellent yields. Overall, the method described does not require solvent switches, in-line purifications, or packed-bed apparatuses due to the judicious manipulation of flow setups and solvent mixtures. | en_US |
| dc.description.sponsorship | DARPA (contract no. ARO W911NF-16-2-0023) | en_US |
| dc.language.iso | en | |
| dc.publisher | American Chemical Society (ACS) | en_US |
| dc.relation.isversionof | 10.1021/ACS.ORGLETT.9B02259 | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | Other repository | en_US |
| dc.title | Modular continuous flow synthesis of imatinib and analogues | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Fu, Wai Chung, and Timothy F. Jamison, "Modular continuous flow synthesis of imatinib and analogues." Organic Letters 21, 15 (July 2019): p. 6112-16 doi 10.1021/ACS.ORGLETT.9B02259 ©2019 Author(s) | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.relation.journal | Organic Letters | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2019-12-18T17:55:25Z | |
| dspace.date.submission | 2019-12-18T17:55:27Z | |
| mit.journal.volume | 21 | en_US |
| mit.journal.issue | 15 | en_US |
| mit.license | PUBLISHER_POLICY | |
| mit.metadata.status | Complete | |
