CuH-Catalyzed Asymmetric Hydroamidation of Vinylarenes
Author(s)Zhou, Yujing; Engl, Oliver D.; Bandar, Jeffrey; Chant, Emma D.; Buchwald, Stephen Leffler
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A CuH-catalyzed enantioselective hydroamidation reaction of vinylarenes has been developed using readily accessible 1,4,2-dioxazol-5-ones as electrophilic amidating reagents. This method provides a straightforward and efficient approach to synthesize chiral amides in good yields with high levels of enantiopurity under mild conditions. Moreover, this transformation tolerates substrates bearing a broad range of functional groups.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Angewandte Chemie International Edition
Zhou, Yujing, et al. "CuH-Catalyzed Asymmetric Hydroamidation of Vinylarenes." Angewandte Chemie International Edition 57, 22 (May 2018): p. 6672-75 doi 10.1002/ANIE.201802797 ©2018 Author(s)
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