Enhanced Dendritic Compartmentalization in Human Cortical Neurons
Author(s)Beaulieu-Laroche, Lou; Toloza, Enrique; Van der Goes, Marie-Sophie; Lafourcade, Mathieu; Barnagian, Derrick G.; Williams, Ziv M.; Eskandar, Emad N.; Frosch, Matthew P.; Cash, Sydney S.; Harnett, Mark T.; ... Show more Show less
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The biophysical features of neurons shape information processing in the brain. Cortical neurons are larger in humans than in other species, but it is unclear how their size affects synaptic integration. Here, we perform direct electrical recordings from human dendrites and report enhanced electrical compartmentalization in layer 5 pyramidal neurons. Compared to rat dendrites, distal human dendrites provide limited excitation to the soma, even in the presence of dendritic spikes. Human somas also exhibit less bursting due to reduced recruitment of dendritic electrogenesis. Finally, we find that decreased ion channel densities result in higher input resistance and underlie the lower coupling of human dendrites. We conclude that the increased length of human neurons alters their input-output properties, which will impact cortical computation. Video Abstract: Human cortical neurons exhibit a higher degree of voltage compartmentalization compared to rodent counterparts due to lower ion channel densities across larger dendritic surfaces.
DepartmentMcGovern Institute for Brain Research at MIT; Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Beaulieu-Laroche, Lou et al. "Enhanced Dendritic Compartmentalization in Human Cortical Neurons." Cell 175, 3 (October 2018): P643-651.e14
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