Contribution of Untargeted Metabolomics for Future Assessment of Biotech Crops
Author(s)Christ, Bastien; Pluskal, Tomáš; Aubry, Sylvain; Weng, Jing-Ke
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The nutritional value and safety of food crops are ultimately determined by their chemical composition. Recent developments in the field of metabolomics have made it possible to characterize the metabolic profile of crops in a comprehensive and high-throughput manner. Here, we propose that state-of-the-art untargeted metabolomics technology should be leveraged for safety assessment of new crop products. We suggest generally applicable experimental design principles that facilitate the efficient and rigorous identification of both intended and unintended metabolic alterations associated with a newly engineered trait. Our proposition could contribute to increased transparency of the safety assessment process for new biotech crops.
DepartmentMassachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research
Trends in Plant Science
Bastien, Christ et al. "Contribution of Untargeted Metabolomics for Future Assessment of Biotech Crops." Trends in Plant Science 23, 12 (December 2018): P1047-1056 © 2018 Elsevier Ltd
Author's final manuscript