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dc.contributor.authorBanigan, Edward J
dc.contributor.authorMirny, Leonid A
dc.date.accessioned2020-07-23T16:11:02Z
dc.date.available2020-07-23T16:11:02Z
dc.date.issued2019-07
dc.date.submitted2019-02
dc.identifier.issn2160-3308
dc.identifier.urihttps://hdl.handle.net/1721.1/126349
dc.description.abstractDuring mitosis, human chromosomes are linearly compacted about 1000-fold by loop-extruding motors. Recent experiments have shown that condensins extrude DNA loops but in a “one-sided” manner. This contrasts with existing models, which predict that symmetric, “two-sided” loop extrusion accounts for mitotic chromosome compaction. We explore whether one-sided extrusion, as it is currently seen in experiments, can compact chromosomes by developing a mean-field theoretical model for polymer compaction by motors that actively extrude loops and dynamically turnover. The model establishes a stringent upper bound of only about tenfold for compaction by strictly one-sided extrusion. We confirm this result with stochastic simulations. Thus, strictly one-sided extrusion as it has been observed so far cannot be the sole mechanism of chromosome compaction. However, as shown by the model, other two-sided or effectively two-sided mechanisms can achieve sufficient compaction.en_US
dc.description.sponsorshipNSF Physics of Living Systems (Grant 15049420)en_US
dc.description.sponsorshipNational Institutes of Health (Grant GM114190)en_US
dc.description.sponsorshipNational Institutes of Health (Grant DK107980)en_US
dc.language.isoen
dc.publisherAmerican Physical Society (APS)en_US
dc.relation.isversionof10.1103/physrevx.9.031007en_US
dc.rightsCreative Commons Attribution 4.0 International licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.sourceAPSen_US
dc.titleLimits of Chromosome Compaction by Loop-Extruding Motorsen_US
dc.typeArticleen_US
dc.identifier.citationBanigan, Edward J. and Leonid A. Mirny. "Limits of Chromosome Compaction by Loop-Extruding Motors." Physical Review X 9, 3 (July 2019): 031007en_US
dc.contributor.departmentMassachusetts Institute of Technology. Institute for Medical Engineering and Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Physicsen_US
dc.relation.journalPhysical Review Xen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2019-10-09T16:56:52Z
dspace.date.submission2019-10-09T16:56:54Z
mit.journal.volume9en_US
mit.journal.issue3en_US


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