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dc.contributor.authorPerrachione, Tyler Kent
dc.contributor.authorDel Tufo, Stephanie Nicole
dc.contributor.authorWinter, Rebecca
dc.contributor.authorMurtagh, Jack
dc.contributor.authorCyr, Abigail B.
dc.contributor.authorChang, Patricia
dc.contributor.authorHalverson, Kelly
dc.contributor.authorGhosh, Satrajit S
dc.contributor.authorChristodoulou, Joanna
dc.contributor.authorGabrieli, John D. E.
dc.date.accessioned2020-07-30T00:44:04Z
dc.date.available2020-07-30T00:44:04Z
dc.date.issued2016-12
dc.date.submitted2016-08
dc.identifier.issn0896-6273
dc.identifier.urihttps://hdl.handle.net/1721.1/126439
dc.description.abstractIdentification of specific neurophysiological dysfunctions resulting in selective reading difficulty (dyslexia) has remained elusive. In addition to impaired reading development, individuals with dyslexia frequently exhibit behavioral deficits in perceptual adaptation. Here, we assessed neurophysiological adaptation to stimulus repetition in adults and children with dyslexia for a wide variety of stimuli, spoken words, written words, visual objects, and faces. For every stimulus type, individuals with dyslexia exhibited significantly diminished neural adaptation compared to controls in stimulus-specific cortical areas. Better reading skills in adults and children with dyslexia were associated with greater repetition-induced neural adaptation. These results highlight a dysfunction of rapid neural adaptation as a core neurophysiological difference in dyslexia that may underlie impaired reading development. Reduced neurophysiological adaptation may relate to prior reports of reduced behavioral adaptation in dyslexia and may reveal a difference in brain functions that ultimately results in a specific reading impairment.en_US
dc.description.sponsorshipNIH (Grant UL1RR025758)en_US
dc.language.isoen
dc.publisherElsevier BVen_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.neuron.2016.11.020en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourcePMCen_US
dc.titleDysfunction of Rapid Neural Adaptation in Dyslexiaen_US
dc.typeArticleen_US
dc.identifier.citationPerrachione, Tyler K. et al. "Dysfunction of Rapid Neural Adaptation in Dyslexia." Neuron 92, 6 (December 2016): P1383-1397 © 2016 Elsevier Incen_US
dc.contributor.departmentMcGovern Institute for Brain Research at MITen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.departmentMassachusetts Institute of Technology. Research Laboratory of Electronicsen_US
dc.relation.journalNeuronen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2019-10-01T13:25:54Z
dspace.date.submission2019-10-01T13:25:57Z
mit.journal.volume92en_US
mit.journal.issue6en_US


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