Design of a load-lock system for the lyophilization of unit-dose pharmaceuticals in a continuous manufacturing machine
Massachusetts Institute of Technology. Department of Mechanical Engineering.
Alexander H. Slocum.
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Lyophilization, or freeze drying, of unit-dose pharmaceuticals eliminates the need to preserve quality through regulated temperature storage during transport. Typical lyophilization is performed through batch processing, but implementing continuous manufacturing instead can lead to improved process control, higher quality product, and increased flexibility. Lyophilization involves four processing chambers at specific pressures and transferring vials between the chambers requires a load lock system. Load lock systems, commonly used in the semiconductor industry, act as a transfer chamber in order to reduce pump-down and venting time of its adjacent processing chambers. This thesis documents the research and design of a load lock system for a continuous manufacturing lyophilization machine.
Thesis: S.B., Massachusetts Institute of Technology, Department of Mechanical Engineering, May, 2020Cataloged from the official PDF of thesis.Includes bibliographical references (pages 65-66).
DepartmentMassachusetts Institute of Technology. Department of Mechanical Engineering
Massachusetts Institute of Technology