Synthesis and optimization of synthetic intermediates to access C21-oxygenated aspidosperma alkaloids

Author(s)
Avci, Nadide Hazal.
Thumbnail
Download1199132256-MIT.pdf (2.145Mb)
Other Contributors
Massachusetts Institute of Technology. Department of Chemistry.
Advisor
Mohammad Movassaghi.
Terms of use
MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided. http://dspace.mit.edu/handle/1721.1/7582
Metadata
Show full item record
Abstract
Synthesis and optimization of C21-oxygenated pentacyclic aspidosperma core is described. A highly effective enzymatic resolution of a non-[beta]-branched primary alcohol (E=22) allowed rapid preparation of both enantiomeric forms of a C21-oxygenated precursor for synthesis of aspidosperma alkaloids.
Description
Thesis: S.M., Massachusetts Institute of Technology, Department of Chemistry, 2020
 
Cataloged from PDF of thesis.
 
Includes bibliographical references.
 
Date issued
2020
URI
https://hdl.handle.net/1721.1/128073
Department
Massachusetts Institute of Technology. Department of Chemistry
Publisher
Massachusetts Institute of Technology
Keywords
Chemistry.
Collections