Seven‐Step Continuous Flow Synthesis of Linezolid Without Intermediate Purification
Author(s)Russell, M. Grace; Jamison, Timothy F
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Herein, the blockbuster antibacterial drug linezolid is synthesized from simple starting blocks by a convergent continuous flow sequence involving seven (7) chemical transformations. This is the highest total number of distinct reaction steps ever performed in continuous flow without conducting solvent exchanges or intermediate purification. Linezolid was obtained in 73 % isolated yield in a total residence time of 27 minutes, corresponding to a throughput of 816 mg h[superscript −1].
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Angewandte Chemie - International Edition
Russell, M. Grace and Timothy F Jamison. "Seven‐Step Continuous Flow Synthesis of Linezolid Without Intermediate Purification." Angewandte Chemie 58, 23 (June 2019): 7678-7681
Author's final manuscript