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dc.contributor.advisorKripa K. Varanasi.en_US
dc.contributor.authorJayaprakash, Vishnu.en_US
dc.contributor.otherMassachusetts Institute of Technology. Department of Mechanical Engineering.en_US
dc.date.accessioned2020-11-03T20:31:41Z
dc.date.available2020-11-03T20:31:41Z
dc.date.copyright2019en_US
dc.date.issued2019en_US
dc.identifier.urihttps://hdl.handle.net/1721.1/128338
dc.descriptionThesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, June, 2019en_US
dc.descriptionCataloged from PDF version of thesis.en_US
dc.descriptionIncludes bibliographical references (pages 31-32).en_US
dc.description.abstractHigh concentration drug formulations that can be delivered via subcutaneous injections offer tremendous benefits to global health, but their high viscosity prevents injectability through medical needles. Current approaches to solve this problem face several challenges ranging from cross contamination and high cost to needle clogging and protein inactivation. Here we report a simple method to enhance formulation injectability through a core annular flow that lubricates viscous transport through a needle. We study the importance of different flow regimes and density based eccentricity in dictating lubrication in the needle. Finally, we quantify the maximum pressure reduction that can be achieved with such a lubricating core annular flow.en_US
dc.description.statementofresponsibilityby Vishnu Jayaprakash.en_US
dc.format.extent32 pagesen_US
dc.language.isoengen_US
dc.publisherMassachusetts Institute of Technologyen_US
dc.rightsMIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.en_US
dc.rights.urihttp://dspace.mit.edu/handle/1721.1/7582en_US
dc.subjectMechanical Engineering.en_US
dc.titleEnhancing the injectability of high concentration drugs via core annular flowsen_US
dc.typeThesisen_US
dc.description.degreeS.M.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineeringen_US
dc.identifier.oclc1201697608en_US
dc.description.collectionS.M. Massachusetts Institute of Technology, Department of Mechanical Engineeringen_US
dspace.imported2020-11-03T20:31:40Zen_US
mit.thesis.degreeMasteren_US
mit.thesis.departmentMechEen_US


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