Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles
Author(s)Melo, Mariane Bandeira; Porter, Ely; Zhang, Yuan; Silva, Murillo; Li, Na; Dobosh, Brian S; Liguori, Alessia; Skog, Pat; Landais, Elise; Menis, Sergey; Sok, Devin; Nemazee, David; Schief, William R.; Weiss, Ron; Irvine, Darrell J; ... Show more Show less
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Self-replicating RNAs derived from alphaviruses have high potential for vaccine applications. Utilizing lipid nanoparticle-formulated RNA replicons as a vaccine platform to deliver self-assembling protein immunogens, Melo et al. demonstrate robust anti-HIV Env antibody production and significantly improved antigen-specific B cell activation in vaccinated mice when compared with protein immunization.
DepartmentMassachusetts Institute of Technology. Synthetic Biology Center; Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Materials Science and Engineering; Koch Institute for Integrative Cancer Research at MIT
Melo, Mariane et al. "Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles." Molecular Therapy 27, 12 (December 2019): P2080-2090 © 2019 The American Society of Gene and Cell Therapy
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