Joint profiling of DNA methylation and chromatin architecture in single cells
Author(s)Li, Guoqiang; Liu, Yaping; Zhang, Yanxiao; Kubo, Naoki; Yu, Miao; Fang, Rongxin; Kellis, Manolis; Ren, Bing; ... Show more Show less
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We report a molecular assay, Methyl-HiC, that can simultaneously capture the chromosome conformation and DNA methylome in a cell. Methyl-HiC reveals coordinated DNA methylation status between distal genomic segments that are in spatial proximity in the nucleus, and delineates heterogeneity of both the chromatin architecture and DNA methylome in a mixed population. It enables simultaneous characterization of cell-type-specific chromatin organization and epigenome in complex tissues.
DepartmentMassachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Springer Science and Business Media LLC
Li, Guoqiang et al. "Joint profiling of DNA methylation and chromatin architecture in single cells." Nature Methods 16, 10 (August 2019): 991–993 © 2019 The Author(s)
Author's final manuscript