Joint profiling of DNA methylation and chromatin architecture in single cells

Author(s)
Li, Guoqiang; Liu, Yaping; Zhang, Yanxiao; Kubo, Naoki; Yu, Miao; ... Show more
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Abstract
We report a molecular assay, Methyl-HiC, that can simultaneously capture the chromosome conformation and DNA methylome in a cell. Methyl-HiC reveals coordinated DNA methylation status between distal genomic segments that are in spatial proximity in the nucleus, and delineates heterogeneity of both the chromatin architecture and DNA methylome in a mixed population. It enables simultaneous characterization of cell-type-specific chromatin organization and epigenome in complex tissues.
Date issued
2019-08
URI
https://hdl.handle.net/1721.1/129395
Department
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Journal
Nature Methods
Publisher
Springer Science and Business Media LLC
Citation
Li, Guoqiang et al. "Joint profiling of DNA methylation and chromatin architecture in single cells." Nature Methods 16, 10 (August 2019): 991–993 © 2019 The Author(s)
Version: Author's final manuscript
ISSN
1548-7091
1548-7105
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