Developing a potential retinal OCT biomarker for local growth of geographic atrophy
Name
boe-11-9-5181.pdf
Description
Published version
Size
1.23 MB
Format
Adobe PDF
Checksum (MD5)
c8b4ea0321b16bb95d5024943d5a7cd8
Author(s)
Yu, Yue
Moult, Eric Michael
Chen, Siyu
Fujimoto, James G
Date Issued
September 2020
Journal
Biomedical Optics Express
Publisher
The Optical Society
Citation
Yu, Yue et al. “Developing a potential retinal OCT biomarker for local growth of geographic atrophy.” Biomedical Optics Express, 11, 9 (September 2020): 399506 © 2020 The Author(s)
Version
Final published version
Abstract
Geographic atrophy (GA), the advanced stage of age-related macular degeneration, is a leading cause of blindness. GA lesions are characterized by anisotropic growth and the ability to predict growth patterns would be valuable in assessing potential therapeutics. In this study, we propose an OCT-based marker of local GA growth rate based on an axial projection of the OCT volume in the Henle fiber layer (HFL) and outer nuclear layer (ONL). We analyze the association between our proposed metric and local GA growth rates in a small longitudinal cohort of patients with AMD. These methods can potentially be used to identify risk markers, stratify patients, or assess response in future therapeutic studies.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Research Laboratory of Electronics
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1364/BOE.399506
