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dc.contributor.authorYu, Yue
dc.contributor.authorMoult, Eric Michael
dc.contributor.authorChen, Siyu
dc.contributor.authorFujimoto, James G
dc.date.accessioned2021-01-25T16:58:31Z
dc.date.available2021-01-25T16:58:31Z
dc.date.issued2020-09
dc.date.submitted2020-07
dc.identifier.issn2156-7085
dc.identifier.urihttps://hdl.handle.net/1721.1/129545
dc.description.abstractGeographic atrophy (GA), the advanced stage of age-related macular degeneration, is a leading cause of blindness. GA lesions are characterized by anisotropic growth and the ability to predict growth patterns would be valuable in assessing potential therapeutics. In this study, we propose an OCT-based marker of local GA growth rate based on an axial projection of the OCT volume in the Henle fiber layer (HFL) and outer nuclear layer (ONL). We analyze the association between our proposed metric and local GA growth rates in a small longitudinal cohort of patients with AMD. These methods can potentially be used to identify risk markers, stratify patients, or assess response in future therapeutic studies.en_US
dc.description.sponsorshipChina Scholarship Council (201806010297)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant 5-R01-EY011289-31)en_US
dc.language.isoen
dc.publisherThe Optical Societyen_US
dc.relation.isversionof10.1364/BOE.399506en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceOSA Publishingen_US
dc.titleDeveloping a potential retinal OCT biomarker for local growth of geographic atrophyen_US
dc.typeArticleen_US
dc.identifier.citationYu, Yue et al. “Developing a potential retinal OCT biomarker for local growth of geographic atrophy.” Biomedical Optics Express, 11, 9 (September 2020): 399506 © 2020 The Author(s)en_US
dc.contributor.departmentInstitute for Medical Engineering and Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Research Laboratory of Electronicsen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.relation.journalBiomedical Optics Expressen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2020-12-15T13:40:06Z
dspace.orderedauthorsYu, Y; Moult, EM; Chen, S; Ren, Q; Rosenfeld, PJ; Waheed, NK; Fujimoto, JGen_US
dspace.date.submission2020-12-15T13:40:10Z
mit.journal.volume11en_US
mit.journal.issue9en_US
mit.licensePUBLISHER_POLICY


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